TMC 435350

Name	TMC 435350
Synonyms	Simeprevir SiMeprevir TMC 435350 Simeprevir(TMC 435350) TMC435,TMC435350,TMC-435350 (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13, 14,14a-tetradecahydro-2-[[7- (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-Methoxy-8-Methyl-2-[4-(1-Methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-Methyl-4,14-dioxocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1 (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide
CAS	923604-59-5
EINECS	689-150-1

biological activity	Simeprevir (TMC-435, TMC-435350) A competitive, reversible, non-covalently bound macrocyclic hepatitis virus (HCV) NS3/4A protease inhibitor directly inhibits HCV virus. It has an average IC50 value of less than 13 nM for HCV NS3/4A(genotypes 1a, 1b, 2, 4, 5, and 6) and 37 nM for genotype 3.
target	TargetValue HCV NS3/4A protease ()
Target	Value
toxic substance data	The information is: pubchem.ncbi.nlm.nih.gov Provide (external link)

Last Update：2024-04-09 21:04:16

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TMC 435350

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